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EXPERIENCED ANALYTICAL SCIENTIST
· Expert
in the research of metalloprotein design/characterization, protein-small molecules conjugation/interaction,
biological
and chemical properties by CD, UV, fluorescence spectroscopy, analytical
ultracentrifugation, dynamic light scattering, SDS-PAGE, MALDI-TOF
·
Extensive
experience years of hands-on experience in protein/peptide
synthesis, modification, purification and de novo design of chemical linker for
specific protein labeling
·
Expertise
in HPLC/SEC, LC-MS, GC, GC-MS method development/validation and
trouble-shooting
·
Experience
with EHS and/or industrial hygiene
·
Accurate,
detailed oriented, multi-task working ability in a fast paced, high output
environment.
·
Outstanding
written and verbal communication skills, independent work ability
EXPERIENCE
Postdoctoral
Associate/Teaching specialist
University
of Minnesota, Twin Cities (2010-Present)
·
Developed
and tested a new protein drug preservation and release hydrogel formulation
Postdoctoral
Fellow
UChicago
Argonne LLC (2009-2010)
·
Developed
and evaluated dye micelles for prostate cancer imaging in surgery
·
Designed
and fabricated a device E-beam by lithography and nanofabrication for early
stage disease diagnosis
·
Developed
the Standard Operation Procedure (SOP) for organic lab
Research
Assistant
Bowling
Green State University (2004-2009)
·
Designed
a series of peptides with different
oligomerization states and investigated the effects of the coordination of
metal ions on their structures by mass spectra
·
Created
a miniature Cu(I) metalloprotein, studied the collisional electron-transfer in
the Marcus inverted region and the effect of diffusion limit
·
Investigated
the electron transfer between the negatively charged metallopeptide and
ferricytochrome c
·
Designed
and synthesized a series of fluorescence quenchers with different of potential
based on ruthenium complexes
·
Developed
a negatively charged metallopeptide probe base on ruthenium complex
·
Designed
a miniature real-time emission-potentiometry and demonstrated its application
in metalloprotein research
Database
developer
Neotrident
Company, Beijing, China (2003-2004)
·
Co-developed
and tested the China Natural Products Database (CNPD)
Research
Assistant
Institute
of Chemistry, Chinese Academy of Sciences (2000-2003)
·
Synthesized
a series of boron subphthalocyanines and europium bis(phthalocyaninato)
complexes
·
Studied
the photochemical and photophysical properties under ambient and high pressure
condition
·
Investigated
the mechanism of increased quantum yield under high pressure condition
EDUCATION
Ph.D.,
Photochemical Sciences, Bowling Green
State University, Bowling Green, OH, Dec, 2009.
Thesis:
Bottom-up
Design of the Synthetic Photoactive Metalloproteins (Advisor: Michael
Ogawa)
M.S.,
Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences,
Beijing, July 2003
Thesis:
Synthesis and spectroscopic properties of sandwich-like bis(phthalocyaninato) europium(III)
and boron subthalocyanine under normal condition and
high pressure condition (Advisor: Guoqiang Yang)
B.S.,
Chemistry, Shandong University, Ji’nan, China, July 2000
Thesis
title: The synthesis of a series of photosensitive materials based on
3-nitro-1-(2,4,6,trimethyl -phenyl)-4-bromine-2-pyrazolin-5-one (Advisor: Miao
Zhang)
AWARDS
“Chinese
Student Academic Awards in BGSU”, 2005
“Outstanding Student Scholarship of Shandong
University” 1997-1999
“Distinguished Student Scholarship of Shandong
province” 1996
SELECTED PUBLICATION AND PATENT
l Wu, S., Fan, J Tong, X.,
Jia, H., Wang P.* “Extreme stabilization of enzymes via molecular
confinement and fast release under electric field”, In preparation
l Fan, J.; Ogawa, M. Y.*
“Effect of Protein Structure on the Driving Force Dependence of Bimolecular
Electron-transfer Rates” Submitted
l Ogawa, M. Y.*; Fan,
J; Fedorova, A.; Hong, J.; Kharenko, O. A.; Kornilova, A. Y.; Lasey, R.C.;
Xie, F. “Electron-transfer
functionality of synthetic coiled-coil metalloproteins” J. Braz. Chem. Soc. 2006, 17(8),
1516-1521.
l Hong, J.; Kharenko, O. A.; Fan,
J.; Xie, F.; Petros, A. K.; Gibney, B. R.; Ogawa, M. Y.* “Evidence that a Miniature Cu(I)
metalloprotein Undergoes Collisional Electron Transfer in the Inverted Marcus
Region.” Angew. Chem. Int. Ed.
2006, (37), 6137-6140.
l Liu, D.; Zhang, J-L.; Fan,
J.; Han, B-X*, Chen, J. “Effect
of CO2 on the Properties of AOT/Water/Isooctane Reverse Micelles by
Fluorescence Study” J. Phys. Chem. B 2004, 108(9), 2851-2856.
l Fan, J.; Li, H.; He, L-M; Xiong, F.;
Li, S-Y; Wang, S-Q; Shen, S-Y; Xu, H-J; Yang, G. “High Pressure Effect on Spectroscopy Properties of Sandwich-like
Europium bis[2,3,9,10,16,17,23,24-octakis(4-methoxyphenoxy)phthalocyninato]” Acta
Chimica Sinica 2004, 62(1), 37-41.
l He, L.; Li, H.; Fan, J.;
Li, S.; Gan, Q.; Zhang, G.; Zhang, B.; Li, Y.; Yang, G. “High Pressure Effect on the Intramolecular
Electron Transfer Process” Chem. Phys. Lett. 2003, 378(34), 263-268.
l Hu, J.;
Sui, Z.; Qin, H.; Lu, H.; Fan, J.
“Preparation
of nickel nanoparticles” Faming Zhuanli Shenqing Gongkai
Shuomingshu China Patent CN20011007728
20010109 (2001).
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